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Endocrine Abstracts

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ea0090oc6.3 | Oral Communications 6: Endocrine-related Cancer | ECE2023

Tumor microenvironment of adrenocortical carcinoma dissected by single-cell RNA-sequencing

Jouinot Anne , Martin Yoann , Foulonneau Thomas , Bendjelal Yanis , Calvet Philip , Violon Florian , Sibony Mathilde , Daniel De Murat , Armignacco Roberta , Perlemoine Karine , Letourneur Franck , Izac Brigitte , Andrieu Muriel , Berthon Annabel , Ragazzon Bruno , Groussin Lionel , Libe Rossella , Bertherat Jerome , Assie Guillaume

Background: Molecular classification is important for diagnosis and prognosis of adrenocortical tumors (ACT). Transcriptome profiles separate benign ACT (“C2” cluster) from carcinomas (ACC) and identify two groups of ACC, “C1A” (“steroid” and “proliferation” signatures) and “C1B” (“immune” signature), of poor and better prognosis respectively. However, these signatures were characterized at the tissue level (“bul...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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